All publications of Emeje Ezekiel . Jos , Nigeria
BREAKING NEWS:THE POSSIBLE VACCINES FOR CORONA VIRUS NOW AVAILABLE Date; 26th March, 2020.To God be the glory.
The corona virus disease also known as Covid-19 is a camouflage of the human influenza virus which has similar characteristics to the avian influenza virus which affects birds. Hence, there are vaccines avialable for COVID-19....
THE POSSIBLE VACCINE FOR COVID-19
To God be the glory, To God be the glory, To God be the glory.
The corona virus disease also known as Covid-19 is acamouflage of the human influenza virus which has similar characteristics to the avian influenza virus which affects birds. Hence, there is the vaccine avialable for COVID-19. The vaccine for Covid-19 of the viral respiratory tract infections for which treatments influenza A and B and Respiratory Syncytial Virus (RSV).Immunization against COVID-19 is the preferred approach.However, antiviral agents are used when patients are allergic to the vaccine.
NATURE OF THE VACCINE
(1) NEURAMINIDASE INHIBITORS:
This vaccine comprises of both OSELTAMIVIR and ZANAMIVIR are effective against both type A and type B influenza viruses. They do not interfere with the immune response to influenza vaccine . Administered prior to exposure neuraminidase inhibitors prevent infection and when administered within 24 to 48 hours after the onset of symptoms they modestly decrease the intesity and duration of symptoms.
(a) HOW IT WORKS;
COVID-19 (Influenza Virus) employ a specific neuramidase that is inserted into the host cell membrane for the purpose of releasing newly formed virons, which is essential for the virus life cycle, but the vaccine which comprises of OSELTAMIVIR and ZANAMIVIR selectively inhibit neuraminidase, thereby preventing the release of new virons and their spread from cell to cell or from human to human comes to a halt.
(b) DRUG REACTIONS;
OSELTAMIVIR is an orally active prodrug, that is rapidly hydrolyzed by the liver to its active form. While ZANAMIVIR is not active orally and is administered via inhalation. Both drugs are eliminated unchange in the urine.
(c) SIDE EFFECTS;
The most common advers effects of OSELTAMIVIR are gastrointestinal(GI) discomfort and nausea, which can be alleviated by taking the drug with food. Irritation of the respiratory tract occurs with ZANSMIVIR. It should be used with caution in individuals with asthma or chronic obstructive pulmonary disease, because bronchospasm may occur.
Mutations of the neuraminidase enzyme have been identified in adults treated with either of the neuraminidase inhibitors.
(2) ADAMANTANE ANTIVIRALS;
The therapeutic spectrum of the ADAMANTANE derivatives AMANTADINE and RIMANTADINE is limited to COVID-19 ( influenza A infections). Due to wide spread resistance, the ABAMANTANES are not recommended in the United States for the treatment or prophylaxis of Influenza A (COVID-19).(N.B not proven to be effective in other countries).
A synthetic guanosine analog, is effective against abroad spectrum of RNA and DNA viruses. Which is used in treatment of immunosuppressived infants and young children with severe RSV infections RIBAVIRIN is also effective in chronic hepatitis C infections, when is it in combination with other Direct Acting AntiVirals (DAAV).
(a) HOW IT WORKS
RIBAVIRIN inhibits replication of RNA and DNA viruses. The drug is first phosphorylated to the 5`-phosphate derivatives. The major product RIBAVIRIN triphosphate exerts its antiviral action by inhibiting guanosine triphosphate formation, preventing viral messenger RNA (mRNA) capping and blocking RNA- dependant RNA polymerase.
(b) DRUG REACTION;
RIBAVIRIN is effective orally and by inhalation. An aerosol is used in the treatment of RSV( respiratory syncytial virus) infection(COVID-19). Absorption is increased if the oral drug is taken with a fatty meal. The drug and its metabolites are eliminated in urine.
(c) SIDE EFFECTS;
This Include dose dependent transient anemia. Elevated bilirubin has also been reported. The aerosol may be safer although respiratory function in infants can deteriorate quickly after initiation of aerosol treatments. Therefore, monitoring is essential. RIBAVIRIN is contraindicated in pregnancy.
(1) To get the contact of a Biologist, Pharmacist, Medical Doctors ( in infectious disease unit), Veterinary Doctors, Immuno-therapist, Researchers, Scientists and the Goverment Authorities.
(2) To give a try of the vaccine on those infected and possibly on those Not infected with the disease.
(3) To ensure the affordability and availability of the COVID-19 vaccine to the entire public.
COMPILED BY; Emeje Ezekiel O.
REFERENCE; Illustrated Reviews of Pharmacology by Lippincott Seventh Edition.